My friend DANNY OZARK co-hosts an open mic at BAR NOIR the second monday of every month. Its comedy/poetry/sexy monologues.
He also hosts an open mic on wednesdays at ABELINE's on South St between 4th and 5th. I know there are comedians, maybe music and poetry, but I'm not sure.
I've been to Helium's open mic as well, its usually pretty good, strictly stand-ups, but I did see the sketch group Animosity Pierre perform there once. You need to get there early to sign up, like 6 or 6:30, show starts around 8pm, I think each gets between 3-5 minutes. Danny usually performs there, he's a nice guy, talk to him there, or contact him on MYSPACE under DANNY OZARK.